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GENETIC FACTORS IN THE DEVELOPMENT OF CHRONIC VENOUS INSUFFICIENCY OF THE VEINS OF THE LOWER EXTREMITIES

Abstract

Chronic venous insufficiency (CVI) is an important medical problem in developed countries. Elevated venous pressure in varicose veins (VV) may contribute to the overexpression of certain matrix metalloproteinases (MMPs) that affect the endothelium, smooth muscle and extracellular matrix proteins of the vein wall [1]. MMP-9 plays a major role in the influx of leukocytes to the site of infection or damaged tissue during inflammatory processes [3].

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References

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